Reactive oxygen species generation at the plasma membrane for antibody control

被引:25
作者
Crane, F. L. [1 ]
Low, H. [2 ]
机构
[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
[2] Karolinska Inst, Dept Mol Med, Stockholm, Sweden
关键词
autoantibody; superoxide; peroxide; NAD(P)H oxidase; NOX;
D O I
10.1016/j.autrev.2008.04.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Generation of reactive oxygen species (ROS) at the plasma membrane can be a vehicle for oxidative unmasking or masking of auto antibodies in a tissue selective and controlled way. There are seven related NADPH oxidases (NOX 1-5, DuoNOX 1,2) which can be activated in various ways to produce superoxide and hydrogen peroxide at the plasma membrane. There is also a plasma membrane NADH oxidase which is under different control. ROS can also be produced by mitochondria or cytosolic oxidases under special conditions. The ROS generation provides oxidant for thiol oxidation or peroxynitrite formation which can be a basis for antibody modification. The specific controls of the oxidases in different tissues allow a basis for localized autoantibody modification in response to stress or environment. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:518 / 522
页数:5
相关论文
共 40 条
[1]   CERULOPLASMIN STIMULATES NADH OXIDATION OF PIG-LIVER PLASMA-MEMBRANE [J].
ALCAIN, FJ ;
VILLALBA, JM ;
LOW, H ;
CRANE, FL ;
NAVAS, P .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 186 (02) :951-955
[2]   IRON REVERSES IMPERMEABLE CHELATOR INHIBITION OF DNA-SYNTHESIS IN CCL-39 CELLS [J].
ALCAIN, FJ ;
LOW, H ;
CRANE, FL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) :7903-7906
[3]   Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells [J].
Bacsi, Attila ;
Woodberry, Mitchell ;
Widger, William ;
Papaconstantinou, John ;
Mitra, Sankar ;
Peterson, Johnny W. ;
Boldogh, Istvan .
MITOCHONDRION, 2006, 6 (05) :235-244
[4]   Two novel proteins activate superoxide generation by the NADPH oxidase NOX1 [J].
Bánfi, B ;
Clark, RA ;
Steger, K ;
Krause, KH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (06) :3510-3513
[5]   Antioxidant pyruvate inhibits cardiac formation of reactive oxygen species through changes in redox state [J].
Bassenge, E ;
Sommer, O ;
Schwemmer, M ;
Bünger, R .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 279 (05) :H2431-H2438
[6]   DIFERRIC TRANSFERRIN REDUCTION BY K562 CELLS - A CRITICAL-STUDY [J].
BERCZI, A ;
SIZENSKY, JA ;
CRANE, FL ;
FAULK, WP .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1073 (03) :562-570
[7]   Regulation of the phagocyte NADPH oxidase by Rac GTPase [J].
Bokoch, Gary M. ;
Zhao, Tieming .
ANTIOXIDANTS & REDOX SIGNALING, 2006, 8 (9-10) :1533-1548
[8]   A GROWTH FACTOR-STIMULATED AND HORMONE-STIMULATED NADH OXIDASE FROM RAT-LIVER PLASMA-MEMBRANE [J].
BRIGHTMAN, AO ;
WANG, J ;
MIU, RKM ;
SUN, IL ;
BARR, R ;
CRANE, FL ;
MORRE, DJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1105 (01) :109-117
[9]   Mitochondrial free radical generation, oxidative stress, and aging [J].
Cadenas, E ;
Davies, KJA .
FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (3-4) :222-230
[10]   Homologs of gp91phox:: cloning and tissue expression of Nox3, Nox4, and Nox5 [J].
Cheng, GJ ;
Cao, ZH ;
Xu, XX ;
Van Meir, EG ;
Lambeth, JD .
GENE, 2001, 269 (1-2) :131-140