Retrocyclin inhibits Gardnerella vaginalis biofilm formation and toxin activity

被引：28

作者：

Hooven, Thomas A. ^{[1
]}

Randis, Tara M. ^{[1
]}

Hymes, Saul R. ^{[1
]}

Rampersaud, Ryan ^{[1
]}

Ratner, Adam J. ^{[1
]}

机构：

[1] Columbia Univ, Dept Pediat, Div Infect Dis, New York, NY 10032 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2012年 / 67卷 / 12期

基金：

美国国家卫生研究院;

关键词：

defensin; vaginolysin; bacterial vaginosis; biofilm; ALPHA-DEFENSINS;

D O I：

10.1093/jac/dks305

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Retrocyclins are cyclic antimicrobial peptides that have been shown to be both broadly active and safe in animal models. RC-101, a synthetic retrocyclin, targets important human pathogens and is a candidate vaginal microbicide. Its activity against microbes associated with bacterial vaginosis is unknown. We investigated the effect of RC-101 on toxin activity, bacterial growth and biofilm formation of Gardnerella vaginalis in vitro. RC-101 potently inhibits the cytolytic activity of vaginolysin, the Gardnerella vaginalis toxin, on both erythrocytes and nucleated cells. RC-101 lacks inhibitory activity against planktonic G. vaginalis but markedly decreases biofilm formation. These dual properties, toxin inhibition and biofilm retardation, justify further exploration of RC-101 as a candidate agent for bacterial vaginosis prevention.

引用

页码：2870 / 2872

页数：3

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