Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus

被引：65

作者：

Maghrani, M

Zeggwagh, NA

Lemhadri, A

El Amraoui, M

Michel, JB

Eddouks, M

机构：

[1] UFR PNPE, Errachidia 52000, Morocco

[2] CHU X, INSERM, U460, F-75018 Paris, France

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 91卷 / 2-3期

关键词：

Fraxinus excelsior; Silybum marianum; diabetes mellitus; streptozotocin; aqueous extract; oral administration; blood glucose;

D O I：

10.1016/j.jep.2004.01.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The hypoglycaemic effect of the aqueous extracts of Fraxinus excelsior (FE) seed and Silybum marianum (SM) aerial part was investigated in normal and streptozotocin (STZ) diabetic rats. After a single dose or 15 daily doses, oral administration of the aqueous extracts (20 mg/kg) Produced a significant decrease of blood glucose levels in both nornial and STZ diabetic rats (P < 0.001). Froin the first week, the body weight was increased in normal rats (P < 0.05) and decreased in STZ rats (P < 0.01) after FE administration. In addition, no changes were observed in basal plasma insulin concentrations after both FE and SM treatments in either normal and STZ diabetic rats indicating that these plants exert their pharmacological activity without affecting insulin secretion. We conclude that the aqueous extracts of FE and SM exhibit potent hypoglycaemic and anti-hyperglycaemic activities in normal and STZ rats, respectively, without affecting basal plasma insulin concentrations. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：309 / 316

页数：8

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