Design and semisynthesis of novel fredericamycin A derivatives with an improved antitumor profile

被引：20

作者：

Abel, Ulrich

Simon, Werner

Peter, Eckard

Hansske, Friedrich G.

机构：

[1] Discovery Partners Int GmbH, D-69123 Heidelberg, Germany

[2] Santhera Pharmaceut, D-69120 Heidelberg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 12期

关键词：

fredericamycin; antitumor; spiro quinone; natural product; semisynthesis;

D O I：

10.1016/j.bmcl.2006.03.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3292 / 3297

页数：6

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