New polyacetylene glucosides from the florets of Carthamus tinctorius and their weak anti-inflammatory activities

被引：53

作者：

He, Jun

Shen, Yi

Jiang, Jian-Shuang

Yang, Ya-Nan

Feng, Zi-Ming

Zhang, Pei-Cheng ^{[1
]}

Yuan, Shao-Peng

Hou, Qi

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Carthamus tinctorius; Polyacetylene glucosides; Structure elucidation; Anti-inflammatory activity; NITRIC-OXIDE; GLYCOSIDES; ALCOHOLS; QUINOCHALCONES; COMPLEXES;

D O I：

10.1016/j.carres.2011.06.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight new linear polyacetylene glucosides (1-8), containing two C-10-, one C-13-and five C-14-acetylenes, together with three known polyacetylenes (9-11) were isolated from the florets of Carthamus tinctorius L. Their structures were elucidated by means of spectroscopic methods and chemical evidence. The absolute configurations of compounds 3-9 were confirmed by Snatzke and Gerards's method, observing the induced circular dichroism after addition of dirhodium tetrakis (trifluoroacetate) [Rh-2(OCOCF3)(4)] in CHCl3. All the isolated compounds (1-11) were also tested for inhibitory activities against LPS-induced NO production in murine macrophages and just showed weak activities at concentrations of 1 x 10 (5) M. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1903 / 1908

页数：6

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