Optical mapping and its potential for large-scale sequencing projects

被引：68

作者：

Aston, C ^{[1
]}

Mishra, B

Schwartz, DC

机构：

[1] Wyeth Ayerst Res, CNS Disorders, Princeton, NJ 08543 USA

[2] NYU, Courant Inst Math Sci, Dept Comp Sci, New York, NY 10003 USA

[3] NYU, WM Keck Lab Biomol Imaging, Dept Chem, New York, NY 10003 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1999年 / 17卷 / 07期

关键词：

D O I：

10.1016/S0167-7799(99)01326-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Physical mapping has been rediscovered as an important component of large-scale sequencing projects. Restriction maps provide landmark sequences at defined intervals, and high-resolution restriction maps can be assembled from ensembles of single molecules by optical means. Such optical maps can be constructed from both large-insert clones and genomic DNA, and are used as a scaffold for accurately aligning sequence contigs generated by shotgun sequencing.

引用

页码：297 / 302

页数：6

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