Engineered bacteriophage-defence systems in bioprocessing

被引:94
作者
Sturino, JM
Klaenhammer, TR
机构
[1] N Carolina State Univ, Genom Sci Program, Raleigh, NC 27695 USA
[2] N Carolina State Univ, Dept Food Sci, Raleigh, NC 27695 USA
关键词
D O I
10.1038/nrmicro1393
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bacteriophages ( phages) have the potential to interfere with any industry that produces bacteria as an end product or uses them as biocatalysts in the production of fermented products or bioactive molecules. Using microorganisms that drive food bioprocesses as an example, this review will describe a set of genetic tools that are useful in the engineering of customized phage-defence systems. Special focus will be given to the power of comparative genomics as a means of streamlining target selection, providing more widespread phage protection, and increasing the longevity of these industrially important bacteria in the bioprocessing environment.
引用
收藏
页码:395 / 404
页数:10
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