Natural polyphenols as proteasome modulators and their role as anti-cancer compounds

被引：70

作者：

Bonfili, Laura ^{[1
]}

Cecarini, Valentina ^{[1
]}

Amici, Manila ^{[1
]}

Cuccioloni, Massimiliano ^{[1
]}

Angeletti, Mauro ^{[1
]}

Keller, Jeffrey N. ^{[2
]}

Eleuteri, Anna M. ^{[1
]}

机构：

[1] Univ Camerino, Dept Mol Cellular & Anim Biol, I-62032 Camerino, MC, Italy

[2] Pennington Biomed Res Ctr, Baton Rouge, LA USA

来源：

FEBS JOURNAL | 2008年 / 275卷 / 22期

关键词：

antioxidant; apoptosis; cancer prevention; cancer therapy; chemical structure; drugs; modulation; natural extracts; polyphenols; proteasome;

D O I：

10.1111/j.1742-4658.2008.06696.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this review is to discuss the effect of natural antioxidant compounds as modulators of the 20S proteasome, a multi-enzymatic multi-catalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell-cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.

引用

页码：5512 / 5526

页数：15

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