Ring-A cleavage of 3-Oxo-olean-12-en-28-oic acid by the fungus Chaetomium longirostre

被引：43

作者：

Shirane, N

Hashimoto, Y

Ueda, K

Takenaka, H

Katoh, K

机构：

[1] Aburahi Laboratories, Shionogi and Co. Ltd., Koka-gun, Shiga 520-34, Koka-cho

来源：

PHYTOCHEMISTRY | 1996年 / 43卷 / 01期

关键词：

Chaetomium longirostre; Chaetomiaceae; fungus; biotransformation; enzymic Baeyer-Villiger oxidation; triterpenes; 3-oxo-olean-12-en-28-oic acid; 3,4-seco-olean-12-en-4-ol-3,28-dioic acid; 3,4-seco-olean-12-en-4,21 beta-diol-3,28-dioic acid; A-homo-3a-oxa-olean-12-en-3-one-28-oic acid;

D O I：

10.1016/0031-9422(96)00266-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3-Oxo-olean-12-en-28-oic acid was transformed by the filamentous fungus Chaetomium longirostre into 3,4-seco-olean-12-en-4-ol-3,28-dioic acid and the 21 beta-hydroxylated compound. A cell-free preparation derived from the fungus converted 3-oxo-olean-12-en-28-oic acid into 3,4-seco-olean-12-en-4-ol-3,28-dioic acid. The ring-A cleavage activity was detected in the soluble fraction of the cell-free preparation and showed a requirement for NADPH. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：99 / 104

页数：6

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