Diving Through the "-Omics": The Case for Deep Phenotyping and Systems Epidemiology

被引：44

作者：

Haring, Robin ^{[1
,2
]}

Wallaschofski, Henri ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany

[2] Boston Univ, Sch Med, Prevent Med & Epidemiol Sect, Boston, MA 02118 USA

来源：

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY | 2012年 / 16卷 / 05期

关键词：

LARGE SOCIAL NETWORK; HUMAN-DISEASE; ASSOCIATION; MEDICINE; BIOLOGY; OBESITY; RISK; MICE; ERA;

D O I：

10.1089/omi.2011.0108

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Enabled by diverse high-throughput technologies, the rapidly evolving field of "-omics sciences" offers the potential to study health and disease in breadth and depth at the human population level. We have recently linked genomics and metabolomics to present the first genome-wide association study of metabolic traits in human urine providing new insights into the functional background of chronic kidney disease. We propose systems epidemiology as a novel approach to study the complexities of human pathophysiology by integrating various population-level omic-metrics and to identify new trans-omic biomarkers.

引用

页码：231 / 234

页数：4

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