Phenotype definition, age, and gender in the genetics of asthma and atopy

被引：26

作者：

Bottema, RW

Reijmerink, NE

Koppelman, GH

Kerkhof, M

Postma, DS

机构：

[1] Univ Groningen, Med Ctr, Dept Pulmonol, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Beatrix Childrens Hosp, Med Ctr, Dept Pediat, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Beatrix Childrens Hosp, Med Ctr, Dept Pediat Pulmonol, NL-9700 RB Groningen, Netherlands

[4] Univ Groningen, Med Ctr, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2005年 / 25卷 / 04期

关键词：

D O I：

10.1016/j.iac.2005.07.002

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma and atopy are complex genetic diseases, with gene-gene and gene-environmental interactions determining its clinical expression. It is important to use a clearly described and objective phenotype in studies on the genetics of asthma and atopy. We discuss the modifying effect of age and gender on the associations between genetic variants and the disease phenotype. Future studies should take these two inherent modifiers into account when studying the genetics of asthma in cross-sectional and longitudinal cohort studies.

引用

页码：621 / +

页数：20

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