Prilling for the development of multi-particulate colon drug delivery systems: Pectin vs. pectin-alginate beads

被引：65

作者：

Auriemma, Giulia ^{[1
]}

Mencherini, Teresa ^{[1
]}

Russo, Paola ^{[1
]}

Stigliani, Mariateresa ^{[1
]}

Aquino, Rita P. ^{[1
]}

Del Gaudio, Pasquale ^{[1
]}

机构：

[1] Univ Salerno, Dept Pharmaceut & Biomed Sci, I-84084 Fisciano, SA, Italy

来源：

CARBOHYDRATE POLYMERS | 2013年 / 92卷 / 01期

关键词：

Colon delivery; Prilling; Pectin/alginate beads; Eudragit coating; Piroxicam; CALCIUM-PECTINATE; GEL BEADS; POLYSACCHARIDES; FORMULATION; POLYMERS; CHITOSAN;

D O I：

10.1016/j.carbpol.2012.09.056

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

This paper proposes a multi-particulate drug delivery system produced by prilling technique in combination with an enteric coating. Optimization of process parameters, such as feed viscosity at nozzle, selection of cross-linker, pH of the gelling solution and cross-linking time, allows to obtain beads with strong gelled matrix. Results showed that dextran/piroxicam beads demonstrated high encapsulation efficiency, very narrow dimensional distribution and high sphericity. Coated beads retained shape and narrow size distribution of the uncoated particles. Moreover, the strength of the produced Zn2+-pectinate beads allows to reduce Eudragit (R) coating thickness. Piroxicam loaded multi-particulate systems show an interesting prolonged drug release in intestinal fluids. Hence, such platforms could be proposed for the treatment of inflammatory bowel diseases. (C) 2012 Elsevier Ltd. All rights reserved.

引用

收藏

页码：367 / 373

页数：7

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