Effect of suckling and adrenergic stimulation on peripheral deiodination in lactating rats: differential expression of type 1 deiodinase mRNA forms

被引：11

作者：

Aceves, C ^{[1
]}

Rojais-Huidobro, R ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Ctr Neurobiol, Dept Neurobiol Celular & Mol, Queretaro 76001, Mexico

来源：

JOURNAL OF ENDOCRINOLOGY | 2001年 / 171卷 / 03期

关键词：

D O I：

10.1677/joe.0.1710533

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous works led us to propose that peripheral iodothyronine deiodination is mainly regulated by the reciprocal interaction between the thyroid and the sympathetic nervous system (SNS). In this study, we analyzed the role suckling exerts, through SNS activation, upon deiodination of thyronines in liver, heart, brown adipose tissue and mammary gland during lactation. Our results showed that resuckling causes a concurrent stimulatory response on deiodinase type 1 (D1) in heart and mammary gland, but not in liver and brown adipose tissue. The stimulatory response was mimicked by norepinephrine and by the beta -adrenergic agonist isoproterenol, through the overexpression of the large form of D1 mRNA. These results suggested that, during lactation, peripheral thyronine deiodination is co-ordinated by the SNS, and suckling is a major modulatory influence.

引用

页码：533 / 540

页数：8

共 25 条

[1]

ACEVES C, 1994, ENDOCRINE, V2, P547

[2] Mammary type I deiodinase is dependent on the suckling stimulus: Differential role of norepinephrine and prolactin [J].

Aceves, C ;

Pineda, O ;

Ramírez-C, I ;

Navarro, MD ;

Valverde-R, C .

ENDOCRINOLOGY, 1999, 140 (07) :2948-2953

[3] Mammary gland sympathetic innervation is a major component in type 1 deiodinase regulation [J].

Aceves, C ;

Rojas-Huidobro, R ;

Marina, N ;

Morales, MT ;

Mena, F .

ENDOCRINE, 1999, 11 (02) :115-121

[4] Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development [J].

Bates, JM ;

Spate, VL ;

Morris, JS ;

St Germain, DL ;

Galton, VA .

ENDOCRINOLOGY, 2000, 141 (07) :2490-2500

[5] PARTITIONING OF NUTRIENTS DURING PREGNANCY AND LACTATION - A REVIEW OF MECHANISMS INVOLVING HOMEOSTASIS AND HOMEORHESIS [J].

BAUMAN, DE ;

CURRIE, WB .

JOURNAL OF DAIRY SCIENCE, 1980, 63 (09) :1514-1529

[6] ALTERNATIVE POLYADENYLATION OF THE AMYLOID PROTEIN-PRECURSOR MESSENGER-RNA REGULATES TRANSLATION [J].

DESAUVAGE, F ;

KRUYS, V ;

MARINX, O ;

HUEZ, G ;

OCTAVE, JN .

EMBO JOURNAL, 1992, 11 (08) :3099-3103

[7] CHANGES IN LIVER IODOTHYRONINE 5'-DEIODINASE ACTIVITY DURING PREGNANCY AND LACTATION IN THE RAT [J].

GIRALT, M ;

IGLESIAS, R ;

VILLARROYA, F ;

MAMPEL, T .

HORMONE AND METABOLIC RESEARCH, 1987, 19 (10) :510-511

[8] Triiodothyronine amplifies the adrenergic stimulation of uncoupling protein expression in rat brown adipocytes [J].

Hernández, A ;

Obregón, MJ .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 278 (05) :E769-E777

[9] FORMATION OF TRI-IODOTHYRONINE AND REVERSE TRI-IODOTHYRONINE FROM THYROXINE IN ISOLATED RAT RENAL TUBULES [J].

HEYMA, P ;

LARKINS, RG ;

STOCKIGT, JR ;

CAMPBELL, DG .

CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1978, 55 (06) :567-572

[10]

HEYMA P, 1980, ENDOCRINOLOGY, V106, P1437, DOI 10.1210/endo-106-5-1437

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