Temporal Analysis of Active and Passive Transport in Living Cells

被引：169

作者：

Arcizet, Delphine ^{[1
,2
,3
,4
]}

Meier, Boern ^{[1
,2
]}

Sackmann, Erich ^{[5
]}

Raedler, Joachim O. ^{[1
,2
]}

Heinrich, Doris ^{[1
,2
]}

机构：

[1] Univ Munich, Ctr NanoSci CeNS, D-80539 Munich, Germany

[2] Univ Munich, Fac Phys, D-80539 Munich, Germany

[3] Univ Paris Diderot, F-75205 Paris, France

[4] CNRS, UMR 7057, Lab Matiere & Syst Complexes, F-75205 Paris 13, France

[5] Tech Univ Munich, Phy Dept E22, D-85748 Garching, Germany

来源：

PHYSICAL REVIEW LETTERS | 2008年 / 101卷 / 24期

关键词：

D O I：

10.1103/PhysRevLett.101.248103

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The cellular cytoskeleton is a fascinating active network, in which Brownian motion is intercepted by distinct phases of active transport. We present a time-resolved statistical analysis dissecting phases of directed motion out of otherwise diffusive motion of tracer particles in living cells. The distribution of active lifetimes is found to decay exponentially with a characteristic time tau(A)=0.65 s. The velocity distribution of active events exhibits several peaks, in agreement with a discrete number of motor proteins acting collectively.

引用

页数：4

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