Caenorhabditis elegans reticulon interacts with RME-1 during embryogenesis

被引：34

作者：

Iwahashi, J

Kawasaki, I

Kohara, Y

Gengyo-Ando, K

Mitani, S

Ohshima, Y

Hamada, N

Hara, K

Kashiwagi, T

Toyoda, T ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Virol, Kurume, Fukuoka 8300011, Japan

[2] Natl Inst Genet, Genome Biol Lab, Ctr Genet Res Informat, Mishima, Shizuoka 4118450, Japan

[3] Tokyo Womens Med Univ, Sch Med, Dept Physiol, Tokyo 1628666, Japan

[4] Kyushu Univ, Grad Sch, Dept Biol, Fac Sci, Fukuoka 8128581, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 293卷 / 02期

关键词：

reticulon; neuroendocrine specific protein; C; elegans; RME-1; endocytosis;

D O I：

10.1016/S0006-291X(02)00282-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reticulon (RTN) family proteins are localized in the endoplasmic reticulum (ER). At least four different RTN genes have been identified in mammals. but in most cases. the functions of the encoded proteins except mammalian RTN4-A and RTN4-B are unknown. Each RTN gene produces 1-3 proteins by different promoters and alternative splicing. In Caenorhabditis elegans, there is a single gene (rtn gene) encoding three reticulon proteins, nRTN-A, B, and C. mRNA of nRTN-C is expressed in germ cells and embryos. However. nRTN-C protein is only expressed during embryogenesis and rapidly disappears after hatch. By yeast two-hybrid screening. two clones encoding the same C-terminal region of RME-1, a protein functioning in the endocytic recycling, were isolated. These findings suggest that nRTN-C functions in the endocytic pathway during embryogenesis. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：698 / 704

页数：7

共 30 条

[1] The Bcl-2 protein family: Arbiters of cell survival [J].