Oxyradical scavenging effects of dehydroascorbate

被引：14

作者：

Devamanoharan, PS ^{[1
]}

Morris, SM ^{[1
]}

Varma, SD ^{[1
]}

机构：

[1] UNIV MARYLAND, DEPT OPHTHALMOL, BALTIMORE, MD 21201 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1996年 / 156卷 / 02期

关键词：

dehydroascorbate; superoxide; hydrogen peroxide; decarboxylation;

D O I：

10.1007/BF00426335

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dehydroascorbate (DHA) has been shown to possess vitamin C like activities as well as to protect the lens against oxidative stress and cataract formation. The results presented here suggest that some of the beneficial effects of DHA can be attributed to its property of undergoing peroxidative decarboxylation and of O-2(radical anion) scavenging. Incubation of 1-C-14-DHA with peroxide at physiological pH has been found to liberate (CO2)-C-14 in quantitative yields, with recovery of 79-94%. The recovery increases with the increase in the amount of DHA used. Its O-2(radical anion) scavenging activity was apparent by inhibition of O-2(radical anion) dependent reduction of ferricytochrome c and nitroblue tetrazolium. The authenticity of the latter mechanism was proved by inhibition of the O-2(radical anion) dependent reactions also by superoxide dismutase.

引用

页码：131 / 134

页数：4

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