Influence of dipalmitoylphosphatidylcholine on the dissolution of Brazilian chrysotile

被引：5

作者：

Valentim, I. B. ^{[1
]}

Martins, M. H. ^{[1
]}

Joekes, I. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP, Brazil

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2008年 / 66卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

dissolution; Brazilian chrysotile; dipaimitoylphosphatidylcholine; lung surfactant;

D O I：

10.1016/j.colsurfb.2008.05.014

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

It is known that Brazilian chrysotile is rapidly removed from the lungs, but quantitative studies about the influence of lung surfactants on chrysotile dissolution have not been investigated. In this work. the chemical behavior of chrysotile and its dissolution in the presence of dipalmitoylphosphatidylcholine (DPPC) were investigated in physiological conditions. The dissolution was investigated through quantification of magnesium and silicon released by chrysotile. At 37 C, the magnesium concentration is similar to control (without DPPC), which is about 2.0 x 10(-4) mol L-1, meaning that the dissolution process is not affected by the presence of this surfactant. The same was observed for silicon. The silicon concentration released by chrysotile is similar in all media tested. It is known that the dissolution mechanisms of brucite and tridymite layers are different. From our results, we propose that under physiological conditions, the mechanism of brucite dissolution is based on its interaction with hydrogen ions and that the mechanism of tridymite dissolution is based on a hydrolysis process. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：96 / 102

页数：7

共 31 条

[1] DISSOLUTION KINETICS OF CHRYSOTILE AT PH 7 TO 10 [J].

BALES, RC ;

MORGAN, JJ .

GEOCHIMICA ET COSMOCHIMICA ACTA, 1985, 49 (11) :2281-2288

[2] The biopersistence of Brazilian chrysotile asbestos following inhalation [J].

Bernstein, DM ;

Rogers, R ;

Smith, P .

INHALATION TOXICOLOGY, 2004, 16 (11-12) :745-761

[3] Comparison of Calidria chrysotile asbestos to pure tremolite: Inhalation biopersistence and histopathology following short-term exposure [J].

Bernstein, DM ;

Chevalier, J ;

Smith, P .

INHALATION TOXICOLOGY, 2003, 15 (14) :1387-1419

[4] The biopersistence of Canadian chrysotile asbestos following inhalation [J].

Bernstein, DM ;

Rogers, R ;

Smith, P .

INHALATION TOXICOLOGY, 2003, 15 (13) :1247-1274

[5] Yeast cells long-term interaction with asbestos fibers [J].

Cassiola, F ;

Rogers, RA ;

Kiyohara, PK ;

Joekes, I .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2005, 41 (04) :277-283

[6] KINETIC STUDY OF DISSOLUTION OF ASBESTOS FIBERS IN WATER [J].

CHOI, I ;

SMITH, RW .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1972, 40 (02) :253-+

[7] Attenuated total reflectance infrared studies of liposome adsorption at the solid-liquid interface [J].

Er, Y ;

Prestidge, CA ;

Fronasiero, D .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2004, 36 (3-4) :147-153

[8] Determination of low levels of free fibres of chrysotile in contaminated soils by X-ray diffraction and FTIR spectroscopy [J].

Foresti, E ;

Gazzano, M ;

Gualtieri, AF ;

Lesci, IG ;

Lunelli, B ;

Pecchini, G ;

Renna, E ;

Roveri, N .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 376 (05) :653-658

[9] Pulmonary surfactant: functions and molecular composition [J].

Goerke, J .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1998, 1408 (2-3) :79-89

[10] LUNG SURFACTANT [J].

HARWOOD, JL .

PROGRESS IN LIPID RESEARCH, 1987, 26 (03) :211-256

← 1 2 3 4 →