RNA recognition by the Vts1p SAM domain

被引：54

作者：

Johnson, PE

Donaldson, LW

机构：

[1] York Univ, Dept Chem, N York, ON M3J 1P3, Canada

[2] York Univ, Dept Biol, N York, ON M3J 1P3, Canada

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 02期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nsmb1039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The putative yeast post-transcriptional regulator Vts1p and its related protein Smaug, from Drosophila melanogaster, each use a sterile alpha motif (SAM) domain to bind an RNA hairpin termed the Smaug recognition element (SRE). Here, we present the NMR structures of the Vts1p - SRE complex and the free SRE. Structural highlights include the direct recognition of a guanine base and the formation or stabilization of a base pair in the SRE loop.

引用

页码：177 / 178

页数：2

共 7 条

[1] The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins [J].