Before They Were Fat: Adipocyte Progenitors

被引：119

作者：

Park, Kye Won ^{[1
,2
]}

Halperin, Daniel S. ^{[1
,2
]}

Tontonoz, Peter ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

CELL METABOLISM | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1016/j.cmet.2008.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adipose tissue mass can expand throughout adult life. Therefore, proliferative adipocyte precursor cells must stand at the ready to respond to increased demand for energy storage. Recent provocative studies have identified discrete immature cell populations from which brown and white adipocytes are derived. This work not only brings fundamental insight into adipose tissue formation but also provides new tools to study how adipogenesis is regulated in pathological conditions such as obesity and diabetes.

引用

页码：454 / 457

页数：4

共 20 条

[1] Cellular program controlling the recovery of adipose tissue mass:: An in vivo imaging approach [J].

Birsoy, Kivanc ;

Soukas, Alexander ;

Torrens, Javier ;

Ceccarini, Giovanni ;

Montez, Jason ;

Maffei, Margherita ;

Cohen, Paul ;

Fayzikhodjaeva, Gulnorakhon ;

Viale, Agnes ;

Socci, Nicholas D. ;

Friedman, Jeffrey M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) :12985-12990

[2] Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice [J].

Gavrilova, O ;

Marcus-Samuels, B ;

Graham, D ;

Kim, JK ;

Shulman, GI ;

Castle, AL ;

Vinson, C ;

Eckhaus, M ;

Reitman, ML .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (03) :271-278

[3] Developmental origin of fat: Tracking obesity to its source [J].

Gesta, Stephane ;

Tseng, Yu-Hua ;

Kahn, C. Ronald .

CELL, 2007, 131 (02) :242-256

[4] MUSCLE DEFICIENCY AND NEONATAL DEATH IN MICE WITH A TARGETED MUTATION IN THE MYOGENIN GENE [J].

HASTY, P ;

BRADLEY, A ;

MORRIS, JH ;

EDMONDSON, DG ;

VENUTI, JM ;

OLSON, EN ;

KLEIN, WH .

NATURE, 1993, 364 (6437) :501-506

[5] ADIPOSE-TISSUE CELLULARITY IN HUMAN OBESITY [J].

HIRSCH, J ;

BATCHELOR, B .

CLINICS IN ENDOCRINOLOGY AND METABOLISM, 1976, 5 (02) :299-311

[6] Obesity as a medical problem [J].

Kopelman, PG .

NATURE, 2000, 404 (6778) :635-643

[7] Life without white fat: a transgenic mouse [J].

Moitra, J ;

Mason, MM ;

Olive, M ;

Krylov, D ;

Gavrilova, O ;

Marcus-Samuels, B ;

Feigenbaum, L ;

Lee, E ;

Aoyama, T ;

Eckhaus, M ;

Reitman, ML ;

Vinson, C .

GENES & DEVELOPMENT, 1998, 12 (20) :3168-3181

[8] Thermoregulation: What role for UCPs in mammals and birds? [J].

Mozo, J ;

Emre, Y ;

Bouillaud, F ;

Ricquier, D ;

Criscuolo, F .

BIOSCIENCE REPORTS, 2005, 25 (3-4) :227-249

[9] Unexpected evidence for active brown adipose tissue in adult humans [J].

Nedergaard, Jan ;

Bengtsson, Tore ;

Cannon, Barbara .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (02) :E444-E452

[10] IMPROVEMENT IN GLUCOSE-TOLERANCE AND INSULIN-RESISTANCE IN OBESE SUBJECTS TREATED WITH TROGLITAZONE [J].

NOLAN, JJ ;

LUDVIK, B ;

BEERDSEN, P ;

JOYCE, M ;

OLEFSKY, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (18) :1188-1193

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