Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same

被引：88

作者：

Sakmar, TP ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, Biochem & Mol Biol Lab, New York, NY 10021 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(02)00306-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The crystal structure of rhodopsin provides significant insights concerning structure/activity relationships in visual pigments and related G-protein-coupled receptors. The specific arrangement of seven-transmembrane helices is stabilized by a series of intermolecular interactions that appear to be conserved among Family A receptors. However, the potential for structural and functional diversity among members of the superfamily of seven-helical receptors presents a significant future challenge.

引用

页码：189 / 195

页数：7

共 48 条

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