Gene for hereditary motor and sensory neuropathy (proximal dominant form) mapped to 3q13.1

被引：33

作者：

Takashima, H

Nakagawa, M

Suehara, M

Saito, M

Saito, A

Kanzato, N

Matsuzaki, T

Hirata, K

Terwilliger, JD

Osame, M

机构：

[1] Kagoshima Univ, Sch Med, Dept Internal Med 3, Kagoshima 890, Japan

[2] Natl Sanotorium Okinawa Hosp, Dept Neurol, Ginowan 90122, Japan

[3] Columbia Univ, Dept Psychiat, New York, NY 10032 USA

[4] Columbia Univ, Columbia Genome Ctr, New York, NY 10032 USA

来源：

NEUROMUSCULAR DISORDERS | 1999年 / 9卷 / 6-7期

关键词：

HMSN-P; linkage mapping; 3q13.1; linkage disequilibrium; HMSN;

D O I：

10.1016/S0960-8966(99)00021-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) has been reported as a new type of HMSN with the disease gene locus in the 3p14.1-q13 region. To further narrow down the gene locus, we performed fine linkage mapping using the linkage disequilibrium method. Analysis of DNA marker haplotypes and genetic cross-over sites showed the disease gene locus to be in the 3.1 cM interval bracketed by D3S1591 and D3S1281. Linkage disequilibrium analysis with DISMULT using 9 marker loci jointly in this region showed a lod score of 4.93 (P < 0.00000095). Consequently, the HMSN-P gene almost certainly lies on chromosome 3q13.1 and shows evidence of Linkage disequilibrium. (C) 1999 Elsevier Science Ireland B.V. All rights reserved.

引用

页码：368 / 371

页数：4

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