Leptin and breast cancer: an overview

被引：32

作者：

Artac, Mehmet ^{[2
]}

Altundag, Kadri ^{[1
]}

机构：

[1] Hacettepe Univ, Dept Med Oncol, Inst Oncol, TR-06100 Ankara, Turkey

[2] Selcuk Univ, Div Med Oncol, Meram Med Fac, Konya, Turkey

来源：

MEDICAL ONCOLOGY | 2012年 / 29卷 / 03期

关键词：

Breast cancer; Leptin; Treatment; Prognosis; MESSENGER-RNA EXPRESSION; BODY-MASS-INDEX; RECEPTOR OB-R; ESTROGEN-RECEPTOR; FACTOR-ALPHA; CELL-LINES; HIP-RATIO; OBESITY; INSULIN; ISOFORMS;

D O I：

10.1007/s12032-011-0056-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Leptin is a well-known mediator of obesity. Leptin and its receptor are overexpressed in breast cancer, especially in high-grade tumors. It has an association with progression and poor survival of breast cancer. Leptin can regulate endothelial cell proliferation and promote angiogenesis. There are several other factors such as insulin and HER2 may be involved in the relationship between leptin and breast cancer. Leptin system has emerged as a new and promising therapeutic target for breast cancer. This review article summarizes the current knowledge about the relation of leptin and breast cancer.

引用

页码：1510 / 1514

页数：5

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