Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol

被引：61

作者：

Hamze, A ^{[1
]}

Provot, O ^{[1
]}

Alami, M ^{[1
]}

Brion, JD ^{[1
]}

机构：

[1] Univ Paris 11, Fac Pharm, CNRS, UMR 8076,BioCIS,Lab Chim Therapeut, F-92296 Chatenay Malabry, France

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 25期

关键词：

D O I：

10.1021/ol052245s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] PtO2- and H2PtCl6-catalyzed hydrosilylation of internal aryl alkynes having a para or an ortho substituent with triethylsilane are discussed and compared. The regioselectivity of the H-Si bond addition was found to be controlled by the ortho substituent rather than the nature of the platinum catalyst. Arylallcynes with an ortho substituent, regardless of its electronic nature, directed the silyl substituent mainly to the a-position. PtO2 proved to be a versatile and powerful catalyst compared to H2PtCl6 since it prevents the alkyne reduction.

引用

页码：5625 / 5628

页数：4

共 34 条

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[2]

2-C

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