High-performance liquid chromatographic determination of quinine in rat biological fluids

被引：18

作者：

Chmurzynski, L ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH MED,TINNITUS RES LAB,BALTIMORE,MD 21201

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 693卷 / 02期

关键词：

quinine;

D O I：

10.1016/S0378-4347(97)00074-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A high-performance liquid chromatographic (HPLC) method with ultraviolet detection for the determination of quinine in rat biological fluids is described. Due to its selectivity and sensitivity, the proposed method can be used in the case of such rat biological fluids as cerebrospinal fluid (CSF) and perilymph for which the accessible volumes are limited to 100 mu l and 10 mu l, respectively. Consequently, the assay method has been applied to the measurements of quinine concentration in rat plasma, CSF and perilymph samples.

引用

页码：423 / 429

页数：7

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