Gold-catallyzed benzylation of arenes and heteroarenes

被引：135

作者：

Mertins, K ^{[1
]}

Lovel, I ^{[1
]}

Kischel, J ^{[1
]}

Zapf, A ^{[1
]}

Beller, M ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 06期

关键词：

arene functionalization; arylation; benzylation; Friedel-Crafts reaction; homogeneous catalysis; gold;

D O I：

10.1002/adsc.200505433

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Friedel-Crafts type benzylation of arenes and heteroarenes with benzylic acetates, alcohols, and carbonates is effectively promoted under mild reaction conditions using catalytic amounts of gold salts. The resulting 1,1-diarylalkanes and 1-aryl-1-heteroarylalkanes are obtained in high yields and with high selectivity. The utility of the method is demonstrated by a short synthesis of beclobrate {ethyl 2-[4-(4-chlorobenzyl)-phenoxy]-2-methylbutyrate (3)}, a fibric acid derivative.

引用

页码：691 / 695

页数：5

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