Finally, mice with CF lung disease

被引：19

作者：

Frizzell, RA ^{[1
]}

Pilewski, JM

机构：

[1] Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15261 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 05期

关键词：

D O I：

10.1038/nm0504-452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing sodium absorption by overexpressing the epithelial sodium channel in mouse airways results in mucus accumulation and inflammation, changes that occur in the lungs of individuals with cystic fibrosis. The development of lung disease in these mice should provide insights into a disease that has long been lacking an animal model (pages 487-493).

引用

页码：452 / 454

页数：4

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