Human CD4+ T cell differentiation and effector function -: Implications for autoimmunity

被引：11

作者：

Davis, LS ^{[1
]}

Schulze-Koops, H ^{[1
]}

Lipsky, PE ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75235 USA

来源：

IMMUNOLOGIC RESEARCH | 1999年 / 19卷 / 01期

基金：

美国国家卫生研究院;

关键词：

human; CD4(+) T cell differentiation; T-helper subsets; autoimmune; rheumatoid arthritis;

D O I：

10.1007/BF02786474

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human CD4(+) memory T cells progress through stages of postthymic differentiation that have been characterized by distinct phenotypes. We have investigated the factors regulating cytokine production, and the correlation between phenotype and effector function in normal and autoimmune individuals. These studies suggest that antigen-induced proliferation in the periphery drives CD4(+) T cells through successive stages of differentiation that culminate in optimal effector function and resistance to external modulatory influences. Moreover, these studies support the concept that in autoimmune individuals, the chronic accumulation of differentiated proinflammatory T cells perpetuate the inflammatory response resulting in aggressive disease.

引用

页码：25 / 34

页数：10

共 28 条

[11] CD27 - MARKER AND MEDIATOR OF T-CELL ACTIVATION [J].

HINTZEN, RQ ;

DEJONG, R ;

LENS, SMA ;

VANLIER, RAW .

IMMUNOLOGY TODAY, 1994, 15 (07) :307-311

[12] THE RELATIONSHIP OF IL-4-PRODUCING AND IFN-GAMMA-PRODUCING T-CELLS STUDIED BY LINEAGE ABLATION OF IL-4-PRODUCING CELLS [J].

KAMOGAWA, Y ;

MINASI, LAE ;

CARDING, SR ;

BOTTOMLY, K ;

FLAVELL, RA .

CELL, 1993, 75 (05) :985-995

[13] A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells [J].

Kaplan, MH ;

Wurster, AL ;

Grusby, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (06) :1191-1196

[14] Enrichment of differentiated CD45RB(dim),CD27- memory T cells in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis [J].

Kohem, CL ;

Brezinschek, RI ;

Wisbey, H ;

Tortorella, C ;

Lipsky, PE ;

OppenheimerMarks, N .

ARTHRITIS AND RHEUMATISM, 1996, 39 (05) :844-854

[15]

LOETSCHER P, 1997, SCIENCE, V277, P2005

[16]

MITCHELL LC, 1989, J IMMUNOL, V142, P1548

[17] Suppression of murine collagen-induced arthritis by nasal administration of collagen [J].

Myers, LK ;

Seyer, JM ;

Stuart, JM ;

Kang, AH .

IMMUNOLOGY, 1997, 90 (02) :161-164

[18] LYMPHOCYTE-RESPONSES AND CYTOKINES [J].

PAUL, WE ;

SEDER, RA .

CELL, 1994, 76 (02) :241-251

[19]

PICKER LJ, 1993, J IMMUNOL, V150, P1105

[20]

Rogge L, 1998, IMMUNOLOGIST, V6, P142

← 1 2 3 →