Long-term consequences of repeated pentobarbital anaesthesia on choice reaction time performance in ageing rats

被引：6

作者：

Blokland, A

Honig, W

Jolles, J

机构：

[1] Maastricht Univ, Fac Psychol, Sect Neurocognit, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, Maastricht Brain & Behav Inst, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2001年 / 87卷 / 05期

关键词：

age factors; risk; cognition;

D O I：

10.1093/bja/87.5.781

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Recent studies have suggested that anaesthesia may be a factor in cognitive decline with age. We examined the effect of repeated (eight times) anaesthesia with pentobarbital on reaction time performance in rats in a longitudinal study. Treated rats had faster response times and made more premature responses than the control rats when they were older than 21 months. The results suggest that repeated anaesthesia during the lifespan can lead to an increase in impulsivity, as assessed by a choice reaction time test, during the later stages of life in the rat. These findings support the theory that repeated anaesthesia is a biological factor that affects cognitive ageing.

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收藏

页码：781 / 783

页数：3

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