Theoretical and practical aspects of fast gas chromatography and method translation

被引:94
作者
Klee, MS
Blumberg, LM
机构
[1] Agilent Technol, Wilmington, DE 19808 USA
[2] Fast GC Consulting, Hockessin, DE 19707 USA
关键词
D O I
10.1093/chromsci/40.5.234
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Interest in the development and implementation of fast gas chromatography (GC) methods continues to increase. Fast GC method development and validation can be simplified and more successful if a few key theoretical and practical concepts are kept in mind. Key concepts such as speed-optimized flow rate, optimal temperature-program rate, sample capacity, "cut the column", and principles of method translation are discussed.
引用
收藏
页码:234 / 247
页数:14
相关论文
共 40 条
[1]  
*AG TECH INC, 1998, GC METH TRANSL FREEW
[2]  
[Anonymous], P 20 INT S CAP CHROM
[3]  
Blumberg L., 1992, P 14 INT S CAP CHROM, P28
[4]   MOLECULAR-BASIS OF PEAK WIDTH IN CAPILLARY GAS-CHROMATOGRAPHY UNDER HIGH COLUMN PRESSURE-DROP [J].
BLUMBERG, LM ;
BERGER, TA .
ANALYTICAL CHEMISTRY, 1993, 65 (19) :2686-2689
[5]  
Blumberg LM, 1999, HRC-J HIGH RES CHROM, V22, P213
[6]  
Blumberg LM, 1999, HRC-J HIGH RES CHROM, V22, P501
[7]   RELATIONS BETWEEN PNEUMATIC PARAMETERS OF IDEAL-GAS IN A COLUMN WITH UNIFORM PERMEABILITY [J].
BLUMBERG, LM .
CHROMATOGRAPHIA, 1995, 41 (1-2) :15-22
[8]  
Blumberg LM, 2000, J MICROCOLUMN SEP, V12, P508, DOI 10.1002/1520-667X(2000)12:9<508::AID-MCS5>3.0.CO
[9]  
2-Y
[10]   Evaluation of column performance in constant pressure and constant flow capillary gas chromatography [J].
Blumberg, LM ;
Wilson, WH ;
Klee, MS .
JOURNAL OF CHROMATOGRAPHY A, 1999, 842 (1-2) :15-28