Iodotrimethylsilane-accelerated one-pot synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones:: A novel procedure for the Biginelli-like cyclocondensation reaction at room temperature

被引：32

作者：

Sabitha, G ^{[1
]}

Reddy, KB ^{[1
]}

Srinivas, R ^{[1
]}

Yadav, JS ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

HELVETICA CHIMICA ACTA | 2005年 / 88卷 / 11期

关键词：

D O I：

10.1002/hlca.200590242

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Biginelli-like cyclocondensation reaction is efficiently catalyzed by iodotrimethylsilane (Me(3)Sil) in MeCN. The reaction proceeds at room temperature by a three-component one-pot condensation of ketones with aldehydes and urea to afford 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones in good yields (Scheme 1 and Table).

引用

页码：2996 / 2999

页数：4

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