Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure

被引：5

作者：

Bougdour, A. ^{[1
]}

Sautel, C. F. ^{[1
]}

Cannella, D. ^{[1
]}

Braun, L. ^{[1
]}

Hakimi, M. A. ^{[1
]}

机构：

[1] Univ Grenoble 1, Lab Adaptat & Pathogenie Microorgan, F-38042 Grenoble 9, France

来源：

PARASITE | 2008年 / 15卷 / 03期

关键词：

Apicomplexa; Toxoplasma gondii; chromatin; transcription; epigenetics;

D O I：

10.1051/parasite/2008153206

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The activity state of a gene is determined by a complex regulatory network of co-acting factors affecting the structure of the chromatin into which the gene is embedded. While significant changes of the transcriptome occur during cell differentiation in apicomplexan parasites, basic mechanisms controlling gene expression are still unknown. Recent studies support and expand the concept of the chromatin environment being key factor for the control of transcriptional activity in these lower eukaryotes organisms. Here, we review recent advances in the field of epigenetic gene regulation in Toxoplasma gondii, the model apicomplexan.

引用

页码：206 / 210

页数：5

共 18 条

[1] Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains [J].

Balaji, S ;

Babu, MM ;

Iyer, LM ;

Aravind, L .

NUCLEIC ACIDS RESEARCH, 2005, 33 (13) :3994-4006

[2] Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii [J].

Bhatti, MM ;

Livingston, M ;

Mullapudi, N ;

Sullivan, WJ .

EUKARYOTIC CELL, 2006, 5 (01) :62-76

[3]

CALLEBAUT I, 2005, BMC GENOMICS, V23, P6

[4] Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase [J].

DarkinRattray, SJ ;

Gurnett, AM ;

Myers, RW ;

Dulski, PM ;

Crumley, TM ;

Allocco, JJ ;

Cannova, C ;

Meinke, PT ;

Colletti, SL ;

Bednarek, MA ;

Singh, SB ;

Goetz, MA ;

Dombrowski, AW ;

Polishook, JD ;

Schmatz, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13143-13147

[5] Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii [J].

Gissot, Mathieu ;

Kelly, Krystyna A. ;

Ajioka, James W. ;

Greally, John M. ;

Kim, Kami .

PLOS PATHOGENS, 2007, 3 (06) :709-719

[6] Epigenetics in Apicomplexa:: control of gene expression during cell cycle progression, differentiation and antigenic variation [J].

Hakimi, Mohamed-Ali ;

Deitsch, Kirk W. .

CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (04) :357-362

[7]

IYER LM, 2007, INT J PARASITOL 0915

[8] Chromatin modifications and their function [J].

Kouzarides, Tony .

CELL, 2007, 128 (04) :693-705

[9] The transcription machinery and the molecular toolbox to control gene expression in Toxoplasma gondii and other protozoan parasites [J].

Meissner, M ;

Soldati, D .

MICROBES AND INFECTION, 2005, 7 (13) :1376-1384

[10] The transcriptome of Toxoplasma gondii [J].

Radke, JR ;

Behnke, MS ;

Mackey, AJ ;

Radke, JB ;

Roos, DS ;

White, MW .

BMC BIOLOGY, 2005, 3 (1)

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