The ABC of auxin transport: The role of p-glycoproteins in plant development

被引:292
作者
Geisler, M
Murphy, AS
机构
[1] Univ Zurich, Inst Plant Biol, Zurich Basel Plant Sci Ctr, CH-8007 Zurich, Switzerland
[2] Purdue Univ, Dept Hort, W Lafayette, IN 47907 USA
关键词
p-glycoprotein; ABC transporter; auxin; multidrug resistance; plant development;
D O I
10.1016/j.febslet.2005.11.054
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A surprising outcome of the Arabidopsis genome project was the annotation of a large number of sequences encoding members of the ABC transporter superfamily, including 22 genes encoding the p-glycoprotein (PGP) subfamily. As mammalian PGP orthologs are associated with multiple drug resistance, plant PGPs were initially presumed to function in detoxification, but were soon seen to have a developmental role. Here, we summarise recent studies of plant PGPs indicating that PGPs mediate the cellular and long-distance transport of the plant hormone auxin. One class of PGPs, represented by AtPGP1, catalyze auxin export, while another class with at least one member, AtPGP4, appears to function in auxin import. Current models on the physiological role of PGPs, their functional interaction and their involvement in cell-to cell (polar) auxin transport are discussed. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1094 / 1102
页数:9
相关论文
共 56 条
[1]   P-glycoprotein: from genomics to mechanism [J].
Ambudkar, SV ;
Kimchi-Sarfaty, C ;
Sauna, ZE ;
Gottesman, MM .
ONCOGENE, 2003, 22 (47) :7468-7485
[2]   Polar transport of auxin: carrier-mediated flux across the plasma membrane or neurotransmitter-like secretion? [J].
Baluska, F ;
Samaj, J ;
Menzel, D .
TRENDS IN CELL BIOLOGY, 2003, 13 (06) :282-285
[3]   What is apical and what is basal in plant root development? [J].
Baluska, F ;
Barlow, PW ;
Baskin, TI ;
Chen, RJ ;
Feldman, L ;
Forde, BG ;
Geisler, M ;
Jernstedt, J ;
Menzel, D ;
Muday, GK ;
Murphy, A ;
Samaj, J ;
Volkmann, D .
TRENDS IN PLANT SCIENCE, 2005, 10 (09) :409-411
[4]   Local, efflux-dependent auxin gradients as a common module for plant organ formation [J].
Benková, E ;
Michniewicz, M ;
Sauer, M ;
Teichmann, T ;
Seifertová, D ;
Jürgens, G ;
Friml, J .
CELL, 2003, 115 (05) :591-602
[5]   The N-1-naphthylphthalamic acid-binding protein is an integral membrane protein [J].
Bernasconi, P ;
Patel, BC ;
Reagan, JD ;
Subramanian, MV .
PLANT PHYSIOLOGY, 1996, 111 (02) :427-432
[6]   Auxin transport [J].
Blakeslee, JJ ;
Peer, WA ;
Murphy, AS .
CURRENT OPINION IN PLANT BIOLOGY, 2005, 8 (05) :494-500
[7]   Relocalization of the PIN1 auxin efflux facilitator plays a role in phototropic responses [J].
Blakeslee, JJ ;
Bandyopadhyay, A ;
Peer, WA ;
Makam, SN ;
Murphy, AS .
PLANT PHYSIOLOGY, 2004, 134 (01) :28-31
[8]   The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots [J].
Blilou, I ;
Xu, J ;
Wildwater, M ;
Willemsen, V ;
Paponov, I ;
Friml, J ;
Heidstra, R ;
Aida, M ;
Palme, K ;
Scheres, B .
NATURE, 2005, 433 (7021) :39-44
[9]   Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts [J].
Borner, GHH ;
Sherrier, DJ ;
Weimar, T ;
Michaelson, LV ;
Hawkins, ND ;
MacAskill, A ;
Napier, JA ;
Beale, MH ;
Lilley, KS ;
Dupree, P .
PLANT PHYSIOLOGY, 2005, 137 (01) :104-116
[10]   Flavonoids act as negative regulators of auxin transport in vivo in Arabidopsis [J].
Brown, DE ;
Rashotte, AM ;
Murphy, AS ;
Normanly, J ;
Tague, BW ;
Peer, WA ;
Taiz, L ;
Muday, GK .
PLANT PHYSIOLOGY, 2001, 126 (02) :524-535