Microparticles for the delivery of DNA vaccines

被引：95

作者：

O'Hagan, DT ^{[1
]}

Singh, M ^{[1
]}

Ulmer, JB ^{[1
]}

机构：

[1] Chiron Corp, Vaccines Res, Emeryville, CA 94608 USA

来源：

IMMUNOLOGICAL REVIEWS | 2004年 / 199卷 / 01期

关键词：

D O I：

10.1111/j.0105-2896.2004.00153.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DNA vaccines have demonstrated a lack of adequate potency in humans, which has necessitated the exploration of various adjunct technologies. Inefficient delivery of DNA vaccines, particularly to antigen-presenting cells, may be contributing to this lack of potency. One effective means of facilitating delivery of DNA vaccines to APCs is through the use of microparticles. In this article, we review the background and rationale for microparticles as a vaccine delivery system, data demonstrating their utility and mode of action for DNA delivery, and the prospects for their development.

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页码：191 / 200

页数：10

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