Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells

被引:317
作者
Dieudonne, Marie-Noelle [1 ]
Bussiere, Marianne [1 ]
Dos Santos, Esther [1 ]
Leneveu, Marie-Christine [1 ]
Giudicelli, Yves [1 ]
Pecquery, Rene [1 ]
机构
[1] Univ Versailles St Quentin, Ctr Hosp Poissy, Fac Med Paris Ile France Ouest, Serv Biochim & Biol Mol,UPRES EA 2493, F-78303 Poissy, France
关键词
adiponectin; adiponectin receptors; MCF-7; proliferation; signal transduction;
D O I
10.1016/j.bbrc.2006.04.076
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is well established that obesity is a risk factor for breast cancer and that blood levels of adiponectin, a hormone mainly secreted by white adipocytes, are inversely correlated with the body fat mass. As adiponectin elicits anti-proliferative effects in some cell types, we tested the hypothesis that adiponectin could influence human breast cancer MCF-7 cell growth. Here we show that MCF-7 cells express adiponectin receptors and respond to human recombinant adiponectin by reducing their growth, AMPkinase activation, and p42/p44 MAPkinase inactivation. Further, we demonstrate that the anti-proliferative effect of adiponectin involves activation of cell apoptosis and inhibition of cell cycle. These findings suggest that adiponectin could act in vivo as a paracrine/endocrine growth inhibitor towards mammary epithelial cells. Moreover, adipose adiponectin production being strongly reduced in obesity, this study may help to explain why obesity is a risk factor of developing breast cancers. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:271 / 279
页数:9
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