Multi-Omics Approaches: The Key to Improving Respiratory Health in People With Cystic Fibrosis?

被引：10

作者：

Lee, Andrew J. ^{[1
,2
]}

Einarsson, Gisli G. ^{[1
,2
]}

Gilpin, Deirdre F. ^{[1
,3
]}

Tunney, Michael M. ^{[1
,3
]}

机构：

[1] Queens Univ Belfast, Halo Res Grp, Belfast, Antrim, North Ireland

[2] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Med Expt, Belfast, Antrim, North Ireland

[3] Queens Univ Belfast, Sch Pharm, Belfast, Antrim, North Ireland

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

cystic fibrosis; inflammation; lungs; metagenomics; microbiome; microbiota; multi-omics; OBSTRUCTIVE PULMONARY-DISEASE; EXHALED BREATH CONDENSATE; GUT MICROBIOTA; ANAEROBIC-BACTERIA; NATURAL-PRODUCTS; COMMENSAL MICROBIOTA; LUNG INFLAMMATION; GENE CLUSTERS; METABOLOMICS; DYSBIOSIS;

D O I：

10.3389/fphar.2020.569821

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The advent of high-throughput multi-omics technologies has underpinned the expansion in lung microbiome research, increasing our understanding of the nature, complexity and significance of the polymicrobial communities harbored by people with CF (PWCF). Having established that structurally complex microbial communities exist within the airways, the focus of recent research has now widened to investigating the function and dynamics of the resident microbiota during disease as well as in health. With further refinement, multi-omics approaches present the opportunity to untangle the complex interplay between microbe-microbe and microbe-host interactions in the lung and the relationship with respiratory disease progression, offering invaluable opportunities to discover new therapeutic approaches for our management of airway infection in CF.

引用

页数：10

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