Do bone marrow cells generate neurons?

被引:21
作者
Hess, DC
Hill, WD
Carroll, JE
Borlongan, CV
机构
[1] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA
[2] Med Coll Georgia, Dept Cell Biol & Anat, Augusta, GA 30912 USA
[3] Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA
[4] Vet Affairs Med Res Serv, Augusta, GA USA
关键词
D O I
10.1001/archneur.61.4.483
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In the past 5 years, accumulating evidence has demonstrated plasticity of bone marrow-derived cells. Bone marrow-derived cells display the capacity to change their fate, differentiating into hepatocytes, endothelial cells, muscle cells, and cardiomyocytes, and even neurons. The findings that bone marrow cells differentiate into neurons in vitro and in vivo challenge previous assumptions that tissue-specific stem cells give rise only to cells of their organ of origin and do not cross lineages.
引用
收藏
页码:483 / 485
页数:3
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