The synthesis of pyrimidin-4-yl substituted α-amino acids.: A versatile approach from alkynyl ketones

被引：75

作者：

Adlington, RM ^{[1
]}

Baldwin, JE ^{[1
]}

Catterick, D ^{[1
]}

Pritchard, GJ ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 08期

关键词：

D O I：

10.1039/a806741d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of amidines with alpha-amino acid alkynyl ketones is shown to be a versatile route to pyrimidin-4-yl substituted alpha-amino acids. This route is also applicable to a parallel synthesis approach and has allowed the formation of a range of pyrimidin-4-yl substituted alpha-amino acids, including the naturally occurring alpha-amino acid L-lathyrine 4.

引用

页码：855 / 866

页数：12

共 26 条

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