IL-1 and anti-inflammatory drugs modulate A beta cytotoxicity in PC12 cells

被引：40

作者：

Fagarasan, MO ^{[1
]}

Aisen, PS ^{[1
]}

机构：

[1] MT SINAI MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10029

来源：

BRAIN RESEARCH | 1996年 / 723卷 / 1-2期

关键词：

Alzheimer's disease; beta-amyloid; interleukin-1; inflammation; indomethacin; dexamethasone; chloroquine;

D O I：

10.1016/0006-8993(96)00259-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of the inflammatory cytokine interleukin-1 beta (IL-1) and several anti-inflammatory drugs on amyloid beta-peptide (A beta) cytotoxicity. Incubation of PC12 cells with 10(-6) M A beta(1-42) for 24 h reduced viabilty to 36%; coincubation with 10(-7) M IL-1 further reduced viability to 13% of baseline. With preincubation of PC12 cells with the drugs indomethacin, dexamethasone and chloroquine, reduction in viabilty was limited to 51%, 48% and 44%, respectively, compared to 32% with A beta alone. These experiments support further study of anti-inflammatory therapy in Alzheimer's disease.

引用

页码：231 / 234

页数：4

共 34 条

[1] ALPHA-1-ANTICHYMOTRYPSIN IS ASSOCIATED SOLELY WITH AMYLOID DEPOSITS CONTAINING THE BETA-PROTEIN - AMYLOID AND CELL LOCALIZATION OF ALPHA-1-ANTICHYMOTRYPSIN [J].