Effect of initial pH on production of ganoderic acid and polysaccharide by submerged fermentation of Ganoderma lucidum

被引：225

作者：

Fang, QH ^{[1
]}

Zhong, JJ ^{[1
]}

机构：

[1] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

PROCESS BIOCHEMISTRY | 2002年 / 37卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Ganoderma lucidum; ganoderic acid; higher fungi; initial pH; polysaccharide; submerged fermentation;

D O I：

10.1016/S0032-9592(01)00278-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of initial pH on simultaneous production of ganoderic acid and a polysaccharide by the fungus Ganoderma lucidum were investigated in shake flasks. An initial pH value, varying within the range of 3.5-7.0. had a significant effect on the cell growth and product biosynthesis. At an initial pH of 6.5, a maximum in biomass of 17.3 +/- 0.12 g/l by dry weight (DW) was obtained, as well as a maximal specific production of ganoderic acid of 1.20 +/- 0.03 mg/100 mg DW and total production of 207.9 +/- 2.7 mg/l. Lowering the initial pH from 6.5 to 3.5 gradually led to a higher production of extracellular polysaccharide and a higher specific production of intracellular polysaccharide. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：769 / 774

页数：6

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