Alkylphospho-L-serine analogues: Synthesis of cytostatically active alkylphosphono derivatives

被引：12

作者：

Brachwitz, H

Olke, M

Bergmann, J

Langen, P

机构：

[1] Max-Delbruck-Ctr. fur Molec. Med.

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(97)00301-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hexadecylphosphono-L-serine (2) was synthesised by phospholipase-D-catalysed transesterification of hexadecylphosphonocholine in the presence of L-serine. The synthesis of beta-O-hexadecylphosphono-L-alanine (10) starting from N-benzyloxycarbonyl-L-serine benzyl ester is reported. The compounds 2 and 10 were found to exhibit cytostatic activity in vitro. (C) 1997 Elsevier Science Ltd.

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页码：1739 / 1742

页数：4

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