mar Operon involved in multidrug resistance of Enterobacter aerogenes

被引：43

作者：

Chollet, R

Bollet, C

Chevalier, J

Malléa, M

Pagès, JM

Davin-Regli, A

机构：

[1] Univ Mediterranee, EA 2197, CJF 9606,Fac Med, Enveloppe Bacterienne Antibiot & Colonisat, F-13385 Marseille 05, France

[2] Univ Mediterranee, EA 2197, CJF 9606,Fac Pharm, Enveloppe Bacterienne Antibiot & Colonisat, F-13385 Marseille 05, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 04期

关键词：

D O I：

10.1128/AAC.46.4.1093-1097.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.

引用

页码：1093 / 1097

页数：5

共 24 条

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