Diagnosis of seronegative chronic hepatitis in tissue

被引：3

作者：

Drebber, U ^{[1
]}

Odenthal, M ^{[1
]}

Dries, V ^{[1
]}

Schirmacher, P ^{[1
]}

Dienes, HP ^{[1
]}

机构：

[1] Univ Cologne, Inst Pathol, D-50931 Cologne, Germany

来源：

PATHOLOGE | 2001年 / 22卷 / 06期

关键词：

chronic hepatitis; histomorphology; viral hepatitis; autoimmune hepatitis; drug-induced injury of the liver;

D O I：

10.1007/s002920100485

中图分类号：

R36 [病理学];

学科分类号：

100104 [病理学与病理生理学];

摘要：

The evaluation of a liver biopsy in chronic hepatitis should make a statement on the etiology and report the degree of activity and stage of the disease. The category of so called seronegative chronic hepatitis may include cases of chronic hepatitis C or infection with other viruses such as the Epstein-Barr virus (EBV) and cytomegalovirus (CMV), cases of marker-negative autoimmune hepatitis as well as drug-induced injury and Wilson's disease in younger patients. In order to establish the diagnosis, sensitive techniques of molecular biology should be applied as well as copper staining by histochemistry. Exact and detailed histopathologic analysis can reveal certain features of autoimmune hepatitis or drug injury.

引用

页码：369 / 374

页数：6

共 14 条

[1]

DESMET VJ, 1994, HEPATOLOGY, V19, P1513, DOI 10.1002/hep.1840190629

[2]

DIENES HP, 1989, Z GASTROENTEROL, V27, P325

[3]

Ishak K. G., 1994, P123

[4]

ISHAK KG, 1994, MODERN PATHOL, V7, P690

[5]

Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly [J].

Kojima, K ;

Nagayama, R ;

Hirama, S ;

Maeda, T ;

Takikawa, H ;

Miyake, K ;

Yamanaka, M ;

Shiga, J .

JOURNAL OF GASTROENTEROLOGY, 1999, 34 (06) :706-712

[6]

Characterization of the overlap syndrome of primary biliary cirrhosis (PBC) and autoimmune hepatitis:: Evidence for it being a hepatitic form of PBC in genetically susceptible individuals [J].

Lohse, AW ;

zum Büschenfelde, KHM ;

Franz, B ;

Kanzler, S ;

Gerken, G ;

Dienes, HP .

HEPATOLOGY, 1999, 29 (04) :1078-1084

[7]

LOHSE AW, 1995, Z GASTROENTEROL, V33, P527

[8]

Autoimmune hepatitis: Clinical manifestations and diagnostic criteria [J].

McFarlane, IG .

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2001, 15 (02) :107-113

[9]

Wilson's disease in patients presenting with liver disease: A diagnostic challenge [J].

Steindl, P ;

Ferenci, P ;

Dienes, HP ;

Grimm, G ;

Pabinger, I ;

Madl, C ;

MaierDobersberger, T ;

Herneth, A ;

Dragosics, B ;

Meryn, S ;

Knoflach, P ;

Granditsch, G ;

Gangl, A .

GASTROENTEROLOGY, 1997, 113 (01) :212-218

[10]

THE WILSON DISEASE GENE IS A COPPER TRANSPORTING ATPASE WITH HOMOLOGY TO THE MENKES DISEASE GENE [J].

TANZI, RE ;

PETRUKHIN, K ;

CHERNOV, I ;

PELLEQUER, JL ;

WASCO, W ;

ROSS, B ;

ROMANO, DM ;

PARANO, E ;

PAVONE, L ;

BRZUSTOWICZ, LM ;

DEVOTO, M ;

PEPPERCORN, J ;

BUSH, AI ;

STERNLIEB, I ;

PIRASTU, M ;

GUSELLA, JF ;

EVGRAFOV, O ;

PENCHASZADEH, GK ;

HONIG, B ;

EDELMAN, IS ;

SOARES, MB ;

SCHEINBERG, IH ;

GILLIAM, TC .

NATURE GENETICS, 1993, 5 (04) :344-350

← 1 2 →