Murine humoral immune response against recombinant structural proteins of hepatitis C virus distinct from those of patients

被引：14

作者：

Ahmed, M ^{[1
]}

Shikata, T ^{[1
]}

Esumi, M ^{[1
]}

机构：

[1] NIHON UNIV,SCH MED,DEPT PATHOL 1,ITABASHI KU,TOKYO 173,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1996年 / 40卷 / 02期

关键词：

hepatitis C virus; antibody; epitope; structural protein;

D O I：

10.1111/j.1348-0421.1996.tb03321.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the humoral immune response to recombinant structural proteins of hepatitis C virus (HCV) such as C, E1 and E2 in immunized mice, Mice showed high induction of antibodies against these three structural proteins, Conformational and/or linear epitopes of these regions showed high responses in mice, Comparison with patients revealed higher anti-E1 and anti-E2 responses in mice and 15 immunoreactive peptides which are unique to mice, especially 11 peptides from the E2 region. The hydrophilic regions of these proteins were found to be the most immunogenic, Therefore, the murine immune system against recombinant El and E2 glycoproteins was distinct from those of patients in natural infection, and may be a target to find protective activity against HCV infection.

引用

页码：169 / 176

页数：8

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