Apoptosis induction by Bcl-2 proteins independent of the BH3 domain

被引：41

作者：

Hossini, Amir M. ^{[1
]}

Eberle, Juergen ^{[1
]}

机构：

[1] Univ Med Berlin, Dept Dermatol & Allergy, Skin Canc Ctr Charite, Charite, Berlin, Germany

来源：

BIOCHEMICAL PHARMACOLOGY | 2008年 / 76卷 / 11期

关键词：

Apoptosis; Bcl-2; proteins; BH3; BH4; Bcl-x;

D O I：

10.1016/j.bcp.2008.08.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bcl-2 proteins, characterized by up to four Bcl-2 homology domains (BH1-BH4), are critical regulators of the mitochondrial proapoptotic pathway. Three major subgroups have been described, namely antiapoptotic proteins, proapoptotic multidomain and BH3-only proteins. These are basic for present models explaining the regulation of the mitochondrial outer membrane permeability. However, several Bcl-2 proteins have been described that do not fit into these models, due to their atypical domain structure or due to their ability to induce apoptosis independently of BH3. These proteins are indicators for new mechanisms in apoptosis control by Bcl-2 proteins, which may supply additional targets for novel therapeutic approaches. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：1612 / 1619

页数：8

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