Efficient amounts of additives for peptide coupling mediated by a water-soluble carbodiimide in aqueous media

被引：25

作者：

Nozaki, S

机构：

[1] Faculty of Pharmaceutical Sciences, Josai University, Sakado

来源：

CHEMISTRY LETTERS | 1997年 / 01期

关键词：

D O I：

10.1246/cl.1997.1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The optimal amounts of HOBt, HOSu, and HONb for enhancement of peptide coupling mediated by EDC in aqueous media were found to be less than equimolar against the C-component or the carbodiimide. A combination of EDC and 0.1 equimolar amount of HOBt was shown to be an effective coupling reagent under aqueous conditions.

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页码：1 / 2

页数：2

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