Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

被引：217

作者：

Faure-Andre, Gabrielle ^{[5
]}

Vargas, Pablo ^{[5
,6
]}

Yuseff, Maria-Isabel ^{[5
]}

Heuze, Melina ^{[5
]}

Diaz, Jheimmy ^{[5
]}

Lankar, Danielle ^{[5
]}

Steri, Veronica ^{[5
]}

Manry, Jeremy ^{[5
]}

Hugues, Stephanie ^{[5
]}

Vascotto, Fulvia ^{[5
]}

Boulanger, Jerome ^{[1
]}

Raposo, Graca ^{[1
]}

Bono, Maria-Rosa ^{[2
,3
,6
]}

Rosemblatt, Mario ^{[2
,3
,4
,6
]}

Piel, Matthieu ^{[1
]}

Lennon-Dumenil, Ana-Maria ^{[5
]}

机构：

[1] Inst Curie, CNRS, UMR144, F-75005 Paris, France

[2] Fdn Ciencia Vida, Santiago, Chile

[3] Inst Milenio Biol Fundamental & Aplicada, Santiago, Chile

[4] Univ Andres Bello, Fac Ciencias Salud, Santiago, Chile

[5] Inst Curie, INSERM, U653, F-75005 Paris, France

[6] Univ Chile, Dept Biol, Fac Ciencias, Santiago 3425, Chile

来源：

SCIENCE | 2008年 / 322卷 / 5908期

关键词：

D O I：

10.1126/science.1159894

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dendritic cells ( DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II- associated invariant chain (li or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild- type DCs alternate between high and low motility, whereas li-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by li depended on the actin- based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.

引用

页码：1705 / 1710

页数：6

共 22 条

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