Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

被引：35

作者：

Puerta, DT

Botta, M

Jocher, CJ

Werner, EJ

Avedano, S

Raymond, KN

Cohen, SM ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Univ Eastern Piedmont A Avogadro, Dept Environm & Life Sci, I-15100 Alessandria, Italy

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 07期

关键词：

D O I：

10.1021/ja057954f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents. Copyright © 2006 American Chemical Society.

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页码：2222 / 2223

页数：2

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