YY1 Over-Expression in Human Brain Gliomas and Meningiomas Correlates with TGF-1, IGF-1 and FGF-2 mRNA Levels

被引：49

作者：

Baritaki, Stavroula ^{[1
,2
]}

Chatzinikola, Anthoula M. ^{[2
]}

Vakis, Antonios F. ^{[3
]}

Soulitzis, Nikolaos ^{[2
,3
]}

Karabetsos, Dimitris A.

Neonakis, Ioannis ^{[2
]}

Bonavida, Benjamin ^{[1
]}

Spandidos, Demetrios A. ^{[2
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[2] Univ Crete, Dept Clin Virol, Iraklion, Crete, Greece

[3] Univ Hosp Crete, Dept Neurosurg, Iraklion, Crete, Greece

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 02期

关键词：

Brain tumor; Glioblastomas; Meningiomas; Real-Time PCR; Growth Factors; YY1; Prognosis; TRANSFORMING-GROWTH-FACTOR; FACTOR-BETA; CELL-PROLIFERATION; PROSTATE-CANCER; UP-REGULATION; IN-VITRO; RECEPTORS; APOPTOSIS; INVASION; VEGF;

D O I：

10.1080/07357900802210760

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study we examined by QRT-PCR the mRNA expression of TGF- 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors. Our findings introduce YY1, for the first time, as a novel gene implicated in brain gliomatogenesis and meningioma establishment. We present a positive correlation between the autocrine expression of YY1 and TGF- 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. We suggest that mRNA profiling of the above genes in the early stages of disease development could be useful for prognostic purposes, and these genes can be considered as potential targets for therapeutic approaches against brain tumors.

引用

页码：184 / 192

页数：9

共 51 条

[1] EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II AND THEIR RECEPTOR MESSENGER-RNAS IN PRIMARY HUMAN ASTROCYTOMAS AND MENINGIOMAS - INVIVO STUDIES USING INSITU HYBRIDIZATION AND IMMUNOCYTOCHEMISTRY [J].

ANTONIADES, HN ;

GALANOPOULOS, T ;

NEVILLEGOLDEN, J ;

MAXWELL, M .

INTERNATIONAL JOURNAL OF CANCER, 1992, 50 (02) :215-222

[2]

Baritaki S, 2007, INT J ONCOL, V31, P69

[3] Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1 [J].

Baritaki, Stavroula ;

Huerta-Yepez, Sara ;

Sakai, Toshiyuki ;

Spandidos, Demetrios A. ;

Bonavida, Benjamin .

MOLECULAR CANCER THERAPEUTICS, 2007, 6 (04) :1387-1399

[4] Epidemiology and etiology of intracranial meningiomas: A review [J].

Bondy, M ;

Ligon, BL .

JOURNAL OF NEURO-ONCOLOGY, 1996, 29 (03) :197-205

[5]

Bristow RE, 1999, CANCER, V85, P658, DOI 10.1002/(SICI)1097-0142(19990201)85:3<658::AID-CNCR16>3.0.CO

[6]

2-M

[7] Influence of epidermal growth factor and gastrin on the cell proliferation of human meningiomas versus astrocytic tumors maintained as ex vivo tissue cultures [J].

Camby, I ;

Nagy, N ;

Rombaut, K ;

Gras, T ;

Duponchelle, C ;

Pasteels, JL ;

Brotchi, J ;

Kiss, R ;

Salmon, I .

NEUROPEPTIDES, 1997, 31 (03) :217-225

[8]

DAUMASDUPORT C, 1988, CANCER-AM CANCER SOC, V62, P2152, DOI 10.1002/1097-0142(19881115)62:10<2152::AID-CNCR2820621015>3.0.CO

[9]

2-T

[10] EFFECTS OF EGF, BFGF, NGF AND PDGF(BB) ON CELL PROLIFERATIVE, MIGRATORY AND INVASIVE CAPACITIES OF HUMAN BRAIN-TUMOR BIOPSIES INVITRO [J].

ENGEBRAATEN, O ;

BJERKVIG, R ;

PEDERSEN, PH ;

LAERUM, OD .

INTERNATIONAL JOURNAL OF CANCER, 1993, 53 (02) :209-214

← 1 2 3 4 5 6 →