The hypocretins as sensors for metabolism and arousal

被引：87

作者：

Adamantidis, Antoine ^{[1
]}

de Lecea, Luis ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2009年 / 587卷 / 01期

关键词：

VENTRAL TEGMENTAL AREA; OREXIN KNOCKOUT MICE; IN-VIVO; LATERAL HYPOTHALAMUS; NEURONAL SYSTEMS; MAMMALIAN SLEEP; BEHAVIOR; RECEPTOR; NARCOLEPSY; GLUCOSE;

D O I：

10.1113/jphysiol.2008.164400

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sleep disturbances are associated with hormonal imbalances and may result in metabolic disorders including obesity and diabetes. Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions. The hypocretin (Hcrt) system is a strong candidate for mediating both sleep and metabolic imbalances because Hcrt neurons are sensitive to metabolic hormones, including leptin and ghrelin, and modulate arousal and goal-orientated behaviours. This review discusses the role of Hcrt neurons as a sensors of energy balance and arousal and proposes new ways of probing local hypothalamic circuits regulating sleep and metabolism with unprecedented cellular specificity and temporal resolution.

引用

页码：33 / 40

页数：8

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