Visible light photoredox organocatalysis: a fully transition metal-free direct asymmetric α-alkylation of aldehydes

被引：140

作者：

Fidaly, Kassim ^{[1
]}

Ceballos, Claire ^{[1
]}

Falguieres, Annie ^{[1
]}

Veitia, Maite Sylla-Iyarreta ^{[1
]}

Guy, Alain ^{[1
]}

Ferroud, Clotilde ^{[1
]}

机构：

[1] ESPCI Paris Tech, CNRS,CNAM, ERL 3193, Lab Transformat Chim & Pharmaceut, F-75003 Paris, France

来源：

GREEN CHEMISTRY | 2012年 / 14卷 / 05期

关键词：

ELECTRON-TRANSFER; SOMO CATALYSIS; SINGLE-LAYER; C-C; OXIDATION; PHOTOCHEMISTRY; PHOTOCATALYSIS; PHOTOPHYSICS; ARYLATION; HYDROGEN;

D O I：

10.1039/c2gc35118h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rose Bengal, a dye sensitizer, was found to be active as a visible light photoredox catalyst for the direct enantioselective alpha-alkylation of aldehydes in environmentally benign and simple conditions. Starting from a SOMO converse mechanism, the catalytic activity of the imidazolidinone organocatalyst was improved using an electrophilic cocatalyst. The resulting methodology and optimal conditions led to efficient and transition-metal-free direct photoredox organocatalysis.

引用

页码：1293 / 1297

页数：5

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